Nurture your brain’s sleep evolution, don’t suppress it. You'll naturally sleep easier, deeper, and longer, if you do.

From 10pm to 7am, your brain isn’t shutting down — it’s running the night shift of your life!

Millions of years of evolution have shaped the human brain to be most active when we think it’s asleep. Strange, but true.

Yet in today’s world, when sleep gets patchy or delayed, many Australians reach for chemical sedatives — medications that dampen brain activity and force it toward unconsciousness. But what if that very intense brain activity is the point of sleep?

New(ish) clinical research, powered by fMRI scanners that show real-time brain activity, reveals a startling truth: REM sleep is anything but restful for your brain. It’s emotionally intense, chemically rich, and absolutely necessary. And so is everything that happens before and after it — from 10pm right through the various phases of sleep to morning dawn. Below is a synopsis of what the brain does each 30 minutes between going to sleep at 10pm and waking up at 7am. 

Read it through then ask yourself a question: Do you really think that hitting your brain with a "chemical hammer" to suppress nighttime activity in healthy adults is prudent, should you want your brain to stay sharp into old age?

10:00 PM – The down-regulation into early phases of sleep begins

You ease into Stage 1 sleep, also known as the hypnagogic transition. Neuronal firing begins to decouple between sensory and association areas. The lateral hypothalamus reduces orexin release, suppressing wake-promoting pathways. Vascular tone in the skin shifts, promoting conductive heat loss. Respiration slows as the medullary centres down regulate CO2 sensitivity. This is a fragile phase — external sounds or light can reverse it. Thermoreceptors in the pre-optic area of the hypothalamus monitor ambient temperature. If it's too high, the descent into deeper sleep halts. Melatonin, secreted by the pineal gland, continues to rise, signalling to peripheral clocks that systemic down-regulation is underway.

10:30 PM – Filtering out the noise

Stage 2 sleep locks in. Brainwaves produce sleep spindles and K-complexes — signals thought to gate sensory input at the thalamus. The baroreflex dampens cardiovascular activity, and core body temperature drops further, relieving the brain of thermal pressure. Autonomic tone shifts: parasympathetic dominance begins. CSF (fluid) movement initiates gently around the fourth ventricle — one of the brain’s central fluid reservoirs located near the brainstem. This early fluid circulation flows through narrow cerebral aqueducts and begins priming the ventricular system for the more vigorous fluid exchange that will come during deep sleep. Pressure gradients begin to build subtly between the ventricles and surrounding tissues, setting the stage for the glymphatic system's overnight "flushing" (clearance) mission.

11:00 PM – First deep clean

Stage 3, or slow-wave sleep (SWS), arrives. Neurons across the cortex begin firing in high-amplitude, low-frequency delta waves, coordinated by thalamocortical feedback loops. This synchrony enables efficient downscaling of synaptic potentiation — a form of neural housekeeping. At the same time, the glymphatic system activates: astrocytic endfeet open aquaporin-4 water channels, widening the perivascular space. Pulsatile arterial pressure from the Circle of Willis drives CSF through these interstitial pathways. Cellular waste — including tau and beta-amyloid proteins — begins clearing. Growth hormone, released from the anterior pituitary under hypothalamic control, supports tissue repair and glucose metabolism. The vagus nerve dominates autonomic tone, reducing cardiac output and gastrointestinal activity, shifting the body's resources inward.

11:30 PM – Deep sleep peaks

This is peak glymphatic "flushing" efficiency. Neuronal shrinkage increases extracellular space by up to 60%, reducing resistance to CSF flow. CSF enters via periarterial channels and is exchanged with interstitial fluid through aquaporin-4 water channels on astrocyte membranes. The movement of waste products toward the perivenous routes clears protein aggregates and metabolic debris. Systemic circulation stabilizes: blood pressure reaches its circadian nadir, and heart rate variability increases due to dominant parasympathetic tone. Hepatic (liver) metabolism of systemic waste products peaks in parallel. Brain glucose utilization drops, with neurons relying more on astrocyte-derived lactate. If core temperature begins rising — due to insulation (excessive bedding) or poor airflow — thermosensitive neurons in the hypothalamus may prompt a brief arousal.

12:00 AM – The dreams softly begin

REM sleep begins. Cortical activity accelerates into beta and gamma frequency ranges. The brainstem’s pontine tegmentum initiates muscle atonia via descending inhibitory projections to spinal motor neurons. Meanwhile, acetylcholine floods the cortex, while serotonin and norepinephrine release from the raphe nuclei and locus coeruleus halt. Visual association areas light up, enabling vivid dream imagery. The amygdala and anterior cingulate cortex become hyperactive, replaying emotional signals stored during the day. Thermoregulation is suspended — the hypothalamus no longer prompts sweating or shivering. The pre-Bötzinger complex adjusts respiratory rhythm to match dream scenarios. If temperature rises above a narrow comfort threshold or interstitial pressure increases from impaired (fluid) drainage, cortical arousal (awakening) may ensue.

12:30 AM – Intermission

You shift back into Stage 2 NREM. Thalamocortical circuits reduce their burst-firing activity. K-complexes reappear, transiently hyperpolarizing cortical neurons, potentially acting as a protective mechanism against awakening. Muscle tone returns modestly, and respiratory rate stabilizes. CSF (fluid) pulsation resumes in the ventricular system, aided by the flexing of arterial walls and the rebound of venous sinus pressure. Baroreceptor input modulates cardiac rhythm to stabilize perfusion. This phase serves as a metabolic reset point before deeper processing resumes. If fluid balance or thermal regulation deviates, micro-awakenings may occur without conscious recall.

1:00 AM – The second flush

You re-enter Stage 3 slow-wave sleep. Cortical neurons hyperpolarise, creating large amplitude delta oscillations. Glymphatic flow intensifies, targeting the medial temporal lobes and hippocampus. Perivascular spaces open wider due to astrocytic modulation of aquaporin-4 channels. During this phase, sharp-wave ripples from the hippocampus coordinate with thalamic sleep spindles and cortical slow oscillations — synchronised patterns believed to underlie memory consolidation. Growth hormone pulses stimulate somatic repair, while glucose transport is temporarily reduced to favor lactate-fueled neural metabolism. Any disruption to these tightly timed bioelectrical and hydraulic processes — from overheating to dehydration — threatens the night's cleanup.

1:30 AM – Emotional REM

Another REM period begins — longer than the last. Cortical desynchrony returns as high-frequency waves dominate EEG patterns. Activity in the amygdala, hippocampus, and anterior cingulate cortex surges, coordinating with cholinergic input from the basal forebrain. These emotional networks reactivate stored affective experiences and initiate memory reconsolidation. CSF (fluid) flow through the glymphatic channels diminishes significantly, as REM physiology favours localised metabolic bursts over fluid exchange. Respiratory variability is governed by brainstem circuits responsive to dream-related imagery. Thermoregulation is silenced. If your ambient environment is too warm or if unresolved cognitive/emotional loads remain, arousal thresholds drop — often culminating in premature awakening or fragmented sleep.

2:00 AM – Floating lightly

You cycle into NREM Stage 2. The thalamus reasserts control over sensory input, gating signals through inhibitory interneurons. EEG reveals spindles modulated by GABAergic cells in the reticular nucleus. Meanwhile, baroreflex sensitivity is restored, modulating autonomic balance as cardiac variability stabilizes. CSF (fluid) pulses lightly between lateral brain ventricles, with minor redistribution of intracranial volume as blood shifts in response to pressure gradients. The hypothalamus monitors vasopressin and aldosterone levels, maintaining water reabsorption and osmolality. Even minor dehydration or circulatory inefficiency at this point can generate homeostatic error signals that trigger transient cortical arousal (awakening).

2:30 AM – The vulnerable wake-up window

REM returns. By now, cortisol levels begin their pre-dawn ascent, driven by activation of the HPA axis and stimulation of CRH and ACTH. For older adults or those with shallow prior sleep, this circadian hormonal transition becomes destabilising. If earlier movement of glymphatic fluids failed to sufficiently clear metabolic waste, neuroinflammatory markers rise, subtly impairing synaptic function and increasing arousability. The anterior insula, sensitive to interoception, may detect bladder pressure, cardiac shifts, or subtle thermal gradients. Combined with reduced melatonin and suppressed thermoregulation, this makes 2:30 AM one of the most common spontaneous wake-up points of the night.

3:00 AM – Teetering between sleep and stirring

Melatonin synthesis winds down as exposure to even trace amounts of light begins resetting the SCN (circadian) clock. Cortisol secretion via the HPA axis ramps up, stimulating gluconeogenesis in the liver and promoting alertness. Locus coeruleus neurons begin firing again, reintroducing norepinephrine into the cortical landscape. The salience network — especially the anterior insula and dorsal anterior cingulate cortex — shows increasing synchrony, scanning for changes in internal and external conditions. Cerebral perfusion increases slightly, raising baseline activity levels. If thermoregulation remains suppressed and the cardiovascular system senses any shift in posture, pressure, or temperature, the RAS (reticular activating system) can trigger preconscious arousal. This is the moment when a single thought, noise, or discomfort can derail sleep.

3:30 AM – REM, again

This REM phase is frequently the most emotionally charged. Cortical theta-gamma coupling enhances synaptic plasticity in prefrontal-limbic circuits. The amygdala, hippocampus, and medial prefrontal cortex engage in high-volume emotional data exchange. Vivid dream content often emerges as a result of this cross-talk. The locus coeruleus remains inhibited, allowing uninterrupted visual and emotional integration. Brainstem cholinergic neurons maintain cortical activation, while REM-on GABAergic neurons enforce muscle atonia. The body cannot thermoregulate, so environmental heat buildup subtly stresses the system. The longer this REM period is allowed to run, the more effectively emotional conflicts and memory fragments from the prior day are restructured — but it is also when sleep is most vulnerable to disruption from external or internal imbalance.

4:00 AM – Fragile stillness

You enter light NREM sleep, predominantly Stage 2. EEG shows intermittent spindles and occasional K-complexes as the brain toggles between maintaining unconsciousness and prepping for reactivation. Autonomic function begins its transition: heart rate and blood pressure creep upward, guided by early morning sympathetic tone. AVP (arginine vasopressin) still suppresses nocturnal urine production, but its influence wanes. The bladder stretches, stimulating pelvic afferents that activate the pontine micturition center. Meanwhile, vestibular and proprioceptive feedback from minor movements may stimulate cortical regions in lighter sleepers. If thermal load has accumulated due to poor ventilation or excessive insulation, hypothalamic thermosensors become sensitized, raising the risk of spontaneous wakefulness.

4:30 AM – One more intense dream

A final REM burst begins — typically the longest and most metabolically active. Glucose uptake spikes in the occipital and limbic regions. The brain’s temperature reaches its peak, driven by dense regional activation and suppressed thermolytic feedback. Acetylcholine floods the forebrain, keeping cortical neurons in a high-frequency firing state. The default mode network re-engages, linking together fragmented memories from earlier REM cycles. The PFC remains partially disengaged, which is why dreams may feel vivid but illogical. If glymphatic drainage was successful earlier, astrocytic swelling has subsided, allowing clear signaling. If not, intracranial pressure or residual metabolic waste may create subtle discomfort, increasing the chance of premature arousal.

5:00 AM – Light sleep, light touch

Stage 1 reappears as a bridge to waking. Thalamocortical connectivity resumes, increasing responsiveness to environmental cues. The brain's arousal systems — including the RAS and basal forebrain — begin ramping up, quietly preparing the cortex to reboot. Sympathetic tone increases, promoting adrenal activity and elevating resting heart rate. Cortisol nears its zenith. If previous sleep cycles were truncated or fragmented, this transition can feel jarring, leading to morning grogginess or sleep inertia. If preserved, this fragile phase sets the stage for one final REM flourish.

5:30 AM – Final REM, final sweep

The final REM stage is a sweeping neurological clean-up. Cortical regions involved in executive function — such as the dorsolateral prefrontal cortex — begin re-engaging. The hippocampus and default mode network coordinate to finalise the emotional and procedural sorting of recent memories. Gamma bursts signal the consolidation of long-term learning. This is the apex of dream richness and emotional recalibration. Meanwhile, cortisol release peaks, priming metabolism, inflammation control, and blood glucose. Successful navigation through this stage correlates with enhanced psychological resilience and emotional adaptability during the day.

6:00 AM – Almost there, as the sun rises

Your hypothalamus begins orchestrating the transition to wakefulness. The suprachiasmatic nucleus (SCN) primes sympathetic reactivation, while thermoregulation resumes — now capable of initiating shivering or sweating responses again. Blood pressure rises due to the early-morning surge of angiotensin II and cortisol. The pineal gland ceases melatonin secretion. REM fragments may still be active at the edges of consciousness, leading to half-dreaming states. Visual sensitivity increases as the retina begins responding to light more acutely, prompting early-stage recalibration of circadian input. If prior sleep was disrupted or REM was insufficient, cortisol may spike prematurely, impacting mood, hunger, and immune response throughout the day.

6:30 AM – Mind on the edge

Melatonin has been suppressed completely. The SCN (circadian clock) aligns tightly with first light, anchoring the next circadian cycle. The default mode network remains active, and fleeting REM imagery may still ripple through prefrontal circuits. This is why dreams — and nightmares — are often remembered during this phase: the dorsolateral prefrontal cortex re-engages just in time to archive the tail end of REM sequences. These last dreams are not always random. Many contain thematic fragments of recent or older memories, reorganised by emotional salience. The brain is deleting the mundane and re-tagging high-impact experiences. In doing so, it’s preserving key emotional markers and discarding mental clutter to make room for today’s new learning.

7:00 AM – Wake up, not shut down

Cortisol peaks sharply, driving final arousal as the hypothalamic-pituitary-adrenal (HPA) axis reaches full activation. Your renal, digestive, and endocrine systems reengage: pancreatic insulin sensitivity rises, gastrointestinal motility resumes, and the adrenal cortex finalises its hormonal morning cocktail. The glymphatic system — having completed its nighttime drainage of interstitial waste — goes dormant, awaiting the next sleep cycle.

The reticular activating system (RAS) sends ascending cholinergic projections to fully awaken the cortex. Meanwhile, the default mode network retracts as task-positive networks come online. If the final REM phase completed without interruption, your brain has just finished re-archiving long-term memories, discarding emotional noise, and updating behavioural strategies based on recent experiences.

If dreams or nightmares linger in your awareness, they are often fragments of older, emotionally tagged memories that were reorganised just before waking — a final neurological filing process that deletes the irrelevant and keeps what still matters.

Waking up now isn’t a reboot. It’s a seamless continuation — the cognitive version of surfacing from deep water, with clarity, calm, and readiness.

Support your brain’s sleep evolution, don’t silence it.

Your brain has been perfecting its overnight performance for millions of years. 

Nurture your brain’s natural rhythms. Drink lots of water during your days. Restrict your intake of digital media in the evenings. Keep your bedroom and bedding cool. And consider a traditional herbal sleep medicine like SLEEPZZZ 7 NIGHTS® to reduce mild anxieties to prevent sleeplessness — variants of which have been sold by German community pharmacists since the 1880s.